Gene drives for malaria control and elimination in Africa

This document examines the use of gene drive technology for the control and elimination of malaria in Africa. It begins by examining the burden of malaria; the gains so far accrued from existing interventions notably vector control, and the need for complementary tools. Gene drive technology has been identified as a potential new option to augment existing interventions in pursuance of achieving the African Union Agenda 2063. This document provides an overview of gene drive as a technology, its readiness for implementation, as well as essential testing pathways and implementation strategies at both country and regional levels, taking into consideration all the possible socio-cultural and ethical issues. Given that there may be potential risks associated with the use of genetic modification technologies, a risk analysis and risk management system has been proposed, mindful of the overwhelming health benefits to be derived from the technology. To ensure safety and the appropriate deployment of this technology, recommendations have been made with regard to policy regulatory systems.

Access the French version of the report through this link.

Second edition of the report can be accessed through this link.