False-negative RDT results and P. falciparum histidine-rich protein 2/3 gene deletions: Information note

False-negative RDT results and P. falciparum histidine-rich protein 2/3 gene deletions

[NOTE: WHO guidance documents are being revised and will be updated by early 2024]

In some countries, increasing levels of histidine-rich protein 2 and 3 (hrp2/3) gene deletions threaten the ability of health providers to diagnose and appropriately treat people infected with P. falciparum malaria.

This information note is intended for national malaria control programme managers and their implementing partners, procurement agencies, national regulatory authorities and manufacturers. It provides specific guidance on the implications of hrp2/3 gene deletions for case management and advises on procedures for investigating suspected false-negative RDT results.