ASTMH 2016, John Lucas: “A promising new mode of action chemistry Indoor Residual Spray product to control resistant mosquitoes”

In collaboration with ASTMH, Image Audiovisuals, and session presenters, MESA brings you this webcast from the 65th ASTMH annual meeting in Atlanta, November 2016.

Title: “A promising new mode of action chemistry Indoor Residual Spray product to control resistant mosquitoes”

Speaker: John Lucas, Sumitomo Chemical Company Ltd

Session information: Scientific Session 12: “Mosquitoes: Operational Control”

Monday, 14 November, 8am – 9:45 am, Marriott – Room A703/704

Abstract:

Widespread insecticide resistance of Anopheline mosquitoes to pyrethroids has dramatically reduced their effectiveness and as a consequence their use in indoor residual spray (IRS) programs has declined dramatically. Currently there are only three other mode of action insecticides recommended by the World Health Organization that are currently in use as IRS adulticides: carbamates, organophosphates and organochlorines, all of which also have cases of resistance reported.  A new mode of action IRS chemistry is therefore urgently needed to control resistant populations and also to help prolong the life of existing IRS chemistry by rotating applications over time between different classes.

SumiShield™ 50 WG is an indoor residual spray product based on the neonicitinoid insecticide clothianidin that has previously not been used in vector control. Initial laboratory studies have shown excellent residual activity of this water dispersible granule (WG) formulation on typical indoor surfaces such as mud, wood and cement. Experimental hut and semi field studies have also been conducted that confirm these initial findings and have shown residual activity of over 6 months against both susceptible and resistant strains. These findings are discussed in detail.
This clothianidin based IRS product is currently undergoing evaluation by the World Health Pesticide Evaluation Scheme (WHOPES) in both experimental huts and also in village scale trials. Introducing an alternative mode of action chemistry to the marketplace will allow use of IRS products to be rotated and thus help facilitate the implementation of the WHO Global Plan for Insecticide Resistance Management (GPRIM). When used alongside other interventions such as bed nets and other modes of action IRS products SumiShield 50 WG will be a valuable tool to help control both susceptible and resistant mosquitoes and bring us closer to the goal of eliminating and ultimately eradicating malaria.