Application of Gene Drive Technology for Malaria Elimination in Africa

Gene drive technology is a genetic engineering tool which changes the genetic composition of a population by ensuring that particular desirable genes are passed on to more offspring than would occur naturally. The application of the technology towards malaria elimination in Africa is currently in its infancy, under development in labs. Concerns are raised over the ethical, ecological, and social implications of the technology. There is a need for comprehensive frameworks to guide their development and deployment, and ongoing dialogue with researchers and communities to limit any unintended consequences of the technology. This brief provides recommendations for policymakers to guide the application of gene drive technology for malaria control.