Which Plasmodium falciparum virulence antigens elicit immunity associated with protection from severe malaria?

Objectives

This project will identify the deadly parasite binding proteins, find out whether antibodies to them are protective, investigate how they bind and determine how common the deadly parasites are.

Principal Institution

University of Melbourne (UoM), Australia

Principal Investigators / Focal Persons

Michael Duffy

Rationale and Abstract

Malaria parasites kill by binding infected cells to blood vessel walls. The binding proteins appear more similar to each other in deadly parasites than in parasites that don’t cause severe malaria. The knowledge obtained from the research will help to develop therapies to block binding and to assess the viability of vaccines.

External reference

Project details

Thematic Categories

Basic Science

Date

Jan 2024 — Dec 2026

Total Project Funding

$601,650

Funding Details

National Health and Medical Research Council (NHMRC) Australia, Australia

Grant ID: 2029583

AUD 890,588