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Last Updated: 16/07/2024

Validation of a complete technological solution (extraction + qPCR) to help the diagnosis of Plasmodium falciparum or Plasmodium vivax in low-resource settings

Objectives

This project intends to add the simplified filter paper-DNA extraction protocol to the portability of the Q3-Plus instrument and the ease of use of gelified ‘ready to use’ quantitative polymerase chain reaction (qPCR) reactions to assemble a complete technological solution that can detect Plasmodium DNA in low-resource or remote areas, such as settlements and gold mining regions in the Amazon.

Principal Investigators / Focal Persons

Alexandre Dias Tavares Costa

Partner Investigators

Dhelio Batista Pereira

Rationale and Abstract

Composed as a kit, the proposed technological solution comprises all steps necessary to perform a molecular base test in the field, allowing health agents to initiate eventual treatments in persistently asymptomatic patients, with no need for the population to travel several hours to the nearest malaria diagnostic center, in the closest city.

Date

Apr 2020 — Jun 2027

Total Project Funding

$371,164

Funding Details
Bill and Melinda Gates Foundation (BMGF), United States

Grand Challenges Brazil. Research on Malaria Prevention, Detection, and Control
Project Site

Brazil

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