Last Updated: 22/03/2024
Unraveling the contribution of Plasmodium vivax metapopulation to the persistence of malaria transmission (MetaVivax)
Objectives
*Original title in Dutch: Ontrafelen van de bijdrage van Plasmodium vivax-metapopulatie aan de persistentie van malaria-overdracht
This project aims to study the contribution of Plasmodium vivax metapopulation in the burden of residual malaria in villages sharing watersheds in the Amazon.
Universidad Peruana Cayetano Heredia (UPCH), Peru
Temple University, United States
Christopher Delgado Ratto
Dionicia Gamboa
Ananias Alberto Escalante
Despite adequate coverage of malaria intervention strategies in rural, remote areas, the elimination efforts vanished after some months, and residual malaria persists. Malaria importation might be playing a significant role in the maintenance of local transmission. From a fundamental perspective, this scenario reflects the metapopulation dynamics theory, where the parasite population’s subdivisions are geographically dispersed but with limited interaction between the components. Events of extinction and recolonization give the maintenance of the metapopulation. For instance, after an adequate intervention, the parasite population might be diminished, but people returning to their villages carrying imported parasites may revert the effect. This project will unravel human mobility’s role in the recolonization event by integrating epidemiological and travel data with the parasite population genetics. This project is the first study to address P. vivax metapopulations as a significant challenge for elimination and seeks to develop a genomics platform that distinguishes among highly related parasites. The expected findings could provide crucial insights about a better design of intervention strategies.
Longitudinal & cross-sectional
Jan 2022 — Dec 2025
$643,091
