Last Updated: 05/11/2024
Study of the role of purinergic receptors in the development of the immune response against experimental malaria
Objectives
*Original in Portuguese: Estudo da participação dos receptores purinérgicos no desenvolvimento da resposta imune contra a malária experimental
The general objective of this project is to characterize the cell damage signal receptors that are involved in the progression of severe forms of experimental malaria and tuberculosis, aiming to interfere in these signaling pathways in order to improve the prognosis of diseases. In addition, this study may unveil new molecular mechanisms involved in the recognition of cell damage and, consequently, expand the understanding and intervention perspectives related to these processes.
Cells dead from tissue damage are quickly phagocytosed, but before disappearing, they alert surrounding cells to activate repair programs. Recognition by the innate immune system of cell damage contributes to the development of inflammatory processes and tissue repair immune responses, but it can also determine the aggravation of damage to damaged tissues. In some cases, uncontrolled cell death can trigger a destructive cascade process that ends up amplifying tissue damage and worsening the prognosis of the disease. These infectious diseases are among the most prevalent in the human species, being jointly responsible for more than 1 million annual deaths worldwide. It is also intended to evaluate the importance of signs of damage in the development of the immune response acquired during these infectious diseases. This study can provide essential knowledge for the development of new therapeutic approaches that can be applied, together with those already used, in the treatment of severe forms of malaria and tuberculosis, as well as other infectious or non-infectious diseases that are characterized by tissue damage. extensive.
Jun 2024 — Oct 2024
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