Last Updated: 05/10/2023
Study of the humoral immune response in recurrent infections by Plasmodium vivax in pregnant women in the Amazon region
Objectives
This project aims to study the profile of the humoral immune response, identifying the impact on pregnancy of multiple recurrences by P. vivax during pregnancy due to the high prevalence and the possible association with important complications during pregnancy.
Malaria in pregnancy is characterized as the presence of Plasmodium spp. in peripheral blood or in the placenta, being one of the main causes of mortality in tropical regions, causing maternal anemia, miscarriage, intrauterine growth restriction, premature delivery and low birth weight. Plasmodium (P.) vivax is the dominant species of malaria outside the African continent, accounting for about 40% of malaria cases in the world. In Brazil, the most prevalent species is also P. vivax, and despite the significant reduction in numbers in recent years, more than 170,000 cases of this parasite are still reported annually. Understanding the mechanisms involved in the immunopathogenesis of the infection during pregnancy will make an important contribution not only to understanding the immunobiology of the disease, but also opening up new avenues of study that may result in a positive prognosis for both the mother and child.
Apr 2021 — Mar 2023
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