Last Updated: 27/05/2024
Strengthening the evidence for policy on the RTS,S/AS01 malaria vaccine: assessment of safety and effectiveness using case-control studies embedded in the Malaria Vaccine Pilot Evaluation (MVPE-CC)
Objectives
To determine the safety and effectiveness of the RTS,S/AS01 malaria vaccine in vaccinated children to complement the population level measures of impact obtained through the WHO’s Malaria Vaccine Implementation Project.
European Vaccine Initiative (EVI), Germany
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
African Research Collaboration for Health Ltd., Kenya
Kenya Medical Research Institute (KEMRI), Kenya
PATH, United States
College of Medicine University of Malawi (UNIMA), Malawi
The ongoing Malaria Vaccine Pilot Evaluation (MVPE) is being conducted in Ghana, Malawi and Kenya through community and sentinel hospital surveillance systems and a series of household surveys (to measure vaccine coverage). The Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) is embedded within MVPE comprising case-control studies of clinical and mortality outcomes. Each case will require four controls and caregiver informed consent will be required prior to study activities. The observational case control studies are measuring as complementary information to what is being collected through MVPE:
- Safety among children who received the malaria vaccine, with focus on cerebral malaria, meningitis and severe malaria.
- The impact of the malaria vaccine on all-cause mortality for boys and girls.
- Promote the use of case-control approaches through Expanded Programmes on Immunization (EPI) and malaria control programmes.
Apr 2021 — Jun 2024
$3.6M
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