Strengthening the evidence for policy on the RTS,S/AS01 malaria vaccine: assessment of safety and effectiveness using case-control studies embedded in the Malaria Vaccine Pilot Evaluation (MVPE-CC)

The ongoing Malaria Vaccine Pilot Evaluation (MVPE) is being conducted in Ghana, Malawi and Kenya through community and sentinel hospital surveillance systems and a series of household surveys (to measure vaccine coverage). The Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) is embedded within MVPE comprising case-control studies of clinical and mortality outcomes. Each case will require four controls and caregiver informed consent will be required prior to study activities. The observational case control studies are measuring as complementary information to what is being collected through MVPE:

1. Safety among children who received the malaria vaccine, with focus on cerebral malaria, meningitis and severe malaria.
2. The impact of the malaria vaccine on all-cause mortality for boys and girls.
3. Promote the use of case-control approaches through Expanded Programmes on Immunization (EPI) and malaria control programmes.

Project details

Product Development
Vaccines (Immune Correlates)

Apr 2021 — Jun 2024

$3.6M

Ghana