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Last Updated: 02/12/2024
Special TES: Efficacy and safety of artemether – lumefantrine and artesunate – amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Mainland Tanzania
Objectives
The objectives of this project are:
- To measure the clinical and parasitological efficacy of AL and ASAQ in patients aged between 6 months and 10 years, suffering from uncomplicated falciparum malaria, by determining the proportion with early treatment failure, late clinical failure, late parasitological failure or an adequate clinical and parasitological response as indicators of efficacy.
- To differentiate recrudescence from new infection by polymerase chain reaction (PCR) analysis.
Secondary objectives :
- To assess the frequency and nature of adverse events
- To determine the polymorphism in molecular markers for artemisinins and partner drugs (lumefantrine and amodiaquine) resistance,
- To assess the parasite clearance rates over the first 72 hours post-treatment, and
- The diversity of parasites and prevalence of hrp2/3 gene deletion in the screened population.
Principal Institution
National Institute for Medical Research (NIMR) Tanzania, Tanzania
Principal Investigators / Focal Persons
Study Design
A one-arm prospective
Thematic Categories
Date
Jan 2022 — Dec 2023
Funding Details
Project Site
Related Resources
