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Last Updated: 17/06/2024
Social affairs and sex in P. falciparum: implications for malaria elimination (SexMal)
Objectives
This project has three main objectives:
- To test if the P. falciparum reproductive transcriptional program changes after substantial drops in malaria transmission driven
- Analyze P. falciparum whole genome sequences to search for signatures of selection on regulatory regions and coding sequences of genes involved in gametocyte development and test for their association with gametocyte-specific transcriptional patterns
- Assess if in-host parasite ecology affects gametocyte investment and determine the relationship of gametocyte-specific transcript levels with Pf genetic diversity and relatedness
Principal Institution
Principal Investigators / Focal Persons
Partner Institutions
Rationale and Abstract
Large-scale malaria elimination programs that quickly reduce the malaria parasite biomass in a community can cause strong selection pressures on the parasite population. One of the major evolutionary forces that can determine parasite strategies for survival, growth, or reproduction is the competition between genetically-diverse parasite strains within the host.
Preliminary data in southern Mozambique suggest that the drastic declines in Plasmodium falciparum transmission achieved through an elimination program are associated with reductions in parasite genetic diversity and increases in gametocyte carriage, therefore supporting the concept that Pf can modulate sexual investment to maximize its within-host competitive ability.
External reference
Thematic Categories
Date
Sep 2021 — Aug 2024
Total Project Funding
$142,966
Funding Details
Project Site
Related Resources
