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Last Updated: 04/05/2024
Safety and immunogenicity of Pfs48/45 in Matrix-M adjuvant in healthy adults in the UK
Objectives
The aim of this study is to assess the safety and immunogenicity of the Plasmodium falciparum malaria vaccine candidate Pfs48/45 in Matrix-M adjuvant in healthy adults living in the UK.
Rationale and Abstract
Volunteers will be recruited into one of three groups (n=8-10 per group) at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford over approximately 12 months. All volunteers will receive three doses of Pfs48/45 in 50 µg Matrix-M, administered intramuscularly and given four weeks apart. Enrolment will be staggered with clinical and safety reviews, follow-up visits, and monitoring via a diary card.
Study Design
Study type: Interventional
Enrollment: 30 participants
Primary purpose: Prevention
Allocation:Non-Randomized
Interventional Model: Parallel assignment
Masking :Open label
NCT number: NCT05400746
Phase: Phase I
External reference
Thematic Categories
Date
Nov 2022 — May 2023
Project Site
Related Resources
