RTSS (Efficacy of GSK Biologicals’ candidate malaria vaccine against malaria disease caused by Plasmodium falciparum infection in infants and children in Africa)

Objectives

The objectives of this project are to assess the following reagrding RTSS vaccine:

1. Efficacy against severe malaria disease.
2. Efficacy against incidence of severe anaemia and malaria hospitalization.
3. Efficacy; duration of efficacy of a primary course.
4. Efficacy; the role of booster dose.
5. Efficacy under different transmission settings.
6. Efficacy agaisnt secondary case definition of clinical malaria disease.
7. Safety of a primary course.
8. Safety of a booster dose.
9. Immunogenicity of a primary course.
10. Immunogenicity of a booster dose.