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Last Updated: 25/02/2025
Role of the bone marrow niche in regulating the haematopoietic stem cell response to infection
Objectives
This project aims to investigate how only a specific subset of stem cells becomes activated to replenish the platelet cell counts. Specifically this project will study the expression and function of specific genes in cells of the environment of stem cells and in stem cells themselves using microscopy- based assays on tissue slices and genetically edited cells implanted into mice.
During infections, such as malaria, which is caused by plasmodium parasites, platelets and red blood cells are destroyed. Hematopoietic stem cells, which are responsible for the production of all the cell types of the blood system, are then put under stress to produce high numbers of platelets and red blood cells. Hematopoietic stem cells are found in the bone marrow, surrounded by many types of other cells. Intravital microscopy will be used to study behaviours of stem cells such as cell division and movement, in the bone marrow in the skull. The results of this project could lead to the development of improved treatments for malaria patients and patients with bone marrow transplants.
Sep 2020 — Sep 2023
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