Research and development on the prevention and treatment of parasitic diseases that are a problem in Japan

Specifically, (1) this project will develop the structure of candidate inhibitors against Entamoeba histolytica, Crypto-Echino, conduct in vivo/ex vivo tests, initial toxicity/safety tests, etc., and conduct late-stage non-clinical studies to clinical studies. Present the lead. (2) Using highly mutated protozoa, elucidate the mechanisms of action of new and existing Entamoeba histolytica drugs and malaria drugs, and predict the frequency of drug resistance. (3) Demonstrate the effect on intestinal bacteria that determine the onset and severity of Entamoeba histolytica and the expression of pathogenic genes of Entamoeba histolytica. (4) Search for inhibitors and drug discovery for Trichomonas acanthus, and (5) elucidate the gene expression, dormancy, and proliferation control essential for creating a malaria vaccine targeting intrahepatic protozoa. The results of this research have social, medical, and economic value by providing leads for new preventive and therapeutic drugs that have a new structure and mechanism of action and are not yet resistant to important domestic parasitic diseases. expected to have.

Drug-based Strategies
Product Development
Vaccines (Immune Correlates)

Apr 2023 — Mar 2026

Japan