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Last Updated: 05/10/2023
Plasmodium escape from protective shells: Species- and stage-specific functions of SERA cysteine proteases in egress from oocysts and erythrocytes
Objectives
This project will explore the molecular mechanisms exerted by SERA cysteine proteases during the egress from oocysts and erythrocytes.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Malarial parasites follow a complex developmental program and have the remarkable capacity to develop inside protected shells. The exit out of red blood cells and cysts in the mosquito vector is unique amongst pathogenic microorganisms. A central role belongs to tailor-made proteases that are only made in Plasmodium and closely related blood parasites. Employing a murine malaria model and cultured human malaria parasites experimental genetics tools will introduce deletions, mutations and labelings into the parasite-encoded genes to permit in-depth microscopic and biochemical studies. The results of this work form a critical stepping stone towards innovative evidence-based strategies to hold parasites captive in their protective shells.
External reference
Thematic Categories
Date
Jan 2021
Funding Details
German Research Foundation (DFG), Germany
Grant number: 446480702
Project Site
Related Resources
