Physiological mechanisms of membrane structures in P. falciparum gametocytes

In this study, the principal investigators identified the conditions under which Plasmodium falciparum gametocytes efficiently form gametocytes. The membrane structures in erythrocytes infected with Plasmodium falciparum gametocytes were subsequently observed by electron microscopy. The results showed that infected erythrocytes have a characteristic membrane structure that differs from that of Plasmodium falciparum cells. Several plasmids for knockdown of proteins transported to erythrocytes during the gametocyte stage and translocon constituent proteins were generated and transfected, and analysis of the genetically modified Plasmodium is currently underway.

Project details

Basic Science

Sep 2020 — Mar 2022

$25,872

Japan