Last Updated: 13/02/2024
P. vivax Genome Variation
Objectives
The P. vivax Genome Variation project aims to understand genome diversity of this parasite that, because it can remain dormant in the liver for years, is particularly hard to eliminate using conventional malaria control measures.
Specific objectives:
- Building a catalogue of P. vivax genome variation
- Providing researchers with standardised genotype data on their samples
- Publishing global analyses of genome variation, population genetics and evolutionary selection
MalariaGEN Resource Centre, Sanger Institute, United Kingdom
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Mahidol Oxford Tropical Medicine Research Unit (MORU), Thailand
National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), United States
University of Oxford, United Kingdom
Shoklo Malaria Research Unit (SMRU), Thailand
Barcelona Institute for Global Health (ISGlobal), Spain
Menzies School of Health Research, Australia
Papua New Guinea Institute of Medical Research (PNGIMR), Papua New Guinea
University of São Paulo (USP), Brazil
Institut Pasteur of Madagascar (IPM), Madagascar
Eijkman Institute for Molecular Biology (EIMB), Indonesia
The P. vivax Genome Variation project is coordinated by the MalariaGEN Resource Centre and connects multiple research groups which are primarily concerned with understanding the population genetics and identifying the genetic causes of antimalarial drug resistance in P. vivax — a major public health concern.
This is a collaborative project, a list of all the partners can be found online: https://www.malariagen.net/projects/p-vivax-genome-variation
A genome-wide catalogue of P. vivax polymorphisms generated by sequencing clinical samples from endemic countries will be created, which we will then use to construct a high-resolution map of genome variation and population genetics.
Nature Genetics 2016; Genomic analysis of local variation and recent evolution in Plasmodium vivax
Jan 2010
Brazil
Cambodia
China
India
Indonesia
Lao PDR
Madagascar
Malaysia
Myanmar
Papua New Guinea
Sri Lanka
Thailand
Vietnam
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