Last Updated: 05/11/2024
New approaches to define protein function during malaria host cell entry
Objectives
Using a multi-disciplinary approach, this project will define cross-species protein function of malaria proteins required for early and late stages of host-cell entry.
Apicomplexan parasites of humans and livestock, including malaria, survive by infecting and reproducing in host-cells. To enable host-cell entry, these parasites evolved sets of unique and shared proteins whose functions remain unknown. Leveraging a substantial international network of research partners, outcomes of benefit to Australia include establishing a lead role in understanding the protein network driving different stages of malaria host-cell entry, characterisation of potential therapeutic targets and advancing imaging techniques applicable to other cellular systems.
Jul 2024 — Jun 2028
$704,423
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