Muscle mass and strength as predictors of time to discharge in patients with COVID-19

The severe acute respiratory syndrome induced by the new coronavirus (SARS-CoV-2) has been declared a worldwide pandemic. Identifying common characteristics of the disease is crucial to promote a better prognosis for patients and to reduce the occurrence of medical complications, the time to medical discharge and mortality rates. Muscle mass and strength are recognized predictive measures of medical complications and mortality in different populations, but it is still unclear whether these also applies to patients with SARS-CoV-2. The researchers working hypothesis is that muscle mass and/or muscle strength are predictive measurements of the time until medical discharge of patients hospitalized with SARS-CoV-2

Prospective Observational Cohort Study

Muscle mass (via ultrasound) and muscle strength (via handgrip) of patients with SARS-CoV-2 will be assessed upon admission, medical discharge and 180 days after medical discharge. The time until medical discharge and any medical complications will be recorded. Throughout the hospitalization period, the mortality rate will also be assessed. One hundred and eighty days after medical discharge, the number of hospital readmissions, mortality rate and the use of public health services will be evaluated, to estimate the cost of each patient to the health service. Patients will be stratified according to muscle mass and strength assessed at admission. Data will be analysed using a mixed model with repeated measures assuming group (percentiles) and time (admission, medical discharge, and 180 days after medical discharge) for each dependent variable. In the event of a significant F-value, Tukey-Kramer post hoc adjustments will be used for multiple purposes. Survival rate will be examined using the Kaplan-Meier curve and analyzed using the Log-rank test (Mantel-Cox). The level of significance will be set apriori at P≤0.05.

Primary Outcome Measures:

• Time to medical discharge [ Time Frame: through the hospitalization period, an average of 15 days ]
• Length (in days) of the time hospitalization until medical discharge

Secondary Outcome Measures :

• All-cause mortality [ Time Frame: through the hospitalization period, an average of 15 days, 60, 180 and 360 days after medical discharge ]
• All-cause mortality rate along the study
• Hospital readmission [ Time Frame: 60, 180 and 360 days after medical discharge ]
• Occurrence of medical complications that require hospitalization

Clinical Trial.gov details

Monitoring & Evaluation

May 2020 — May 2022

Brazil

Clinical Epidemiology of COVID-19 in Malaria Settings