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Last Updated: 19/06/2024

Monoclonal antibodies to placental malaria antigen VAR2CSA

Objectives

To test the antibodies produced by the B cells to find antibodies which can block placental infection, can clear or kill infected cells, and react with many strains.

Principal Investigators / Focal Persons

Stephen Rogerson

Rationale and Abstract

Placental malaria parasites express VAR2CSA protein on the red blood cell surface. From the blood of pregnant women with strong antibody to VAR2CSA, antibody-producing B cells will be isolated. The best antibodies identified after the test will be tweaked to further improve activity. Optimised monoclonal antibody to VAR2CSA may prevent placental malaria.

Thematic Categories

Vaccines (Immune Correlates)

Date

Dec 2022

Total Project Funding

$513,964

Project Site

Australia

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