Last Updated: 19/06/2024
Monoclonal antibodies to placental malaria antigen VAR2CSA
Objectives
To test the antibodies produced by the B cells to find antibodies which can block placental infection, can clear or kill infected cells, and react with many strains.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Placental malaria parasites express VAR2CSA protein on the red blood cell surface. From the blood of pregnant women with strong antibody to VAR2CSA, antibody-producing B cells will be isolated. The best antibodies identified after the test will be tweaked to further improve activity. Optimised monoclonal antibody to VAR2CSA may prevent placental malaria.
Thematic Categories
Date
Dec 2022
Total Project Funding
$513,964
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 2020606
AUD 707,364
Project Site
