Last Updated: 27/03/2015
Mass drug administration of DHA-PQP to accelerate towards malaria elimination in Magude district, Southern Mozambique
Objectives
To assess the feasibility and impact of a malaria elimination intervention package consisting of one round of IRS plus two rounds of MDA on top of high LLIN coverage and standard case management.
Secondary objectives:
- To measure the impact of MDA plus high coverage of vector control tools (IRS) in Magude district using a “before and after” approach and an Interrupted Time Series design
- To evaluate the effectiveness of 2 rounds of community-wide MDA on the outcomes of reducing baseline malaria parasite prevalence and confirmed case incidence over a 12 month period
- To quantify the population coverage of the MDA intervention in the study area, including the identification of systematic barriers to achieving high coverage
- To assess in a subgroup of the study population real adherence of taking a full course of DHA-PIP when not administered through DOT (directly observed treatment)
- To assess the acceptability of participating in the MDA intervention among community members and health care leaders in the District of Magude
- To measure the cost and cost-effectiveness of MDAs
Principal Investigators / Focal Persons
Rationale and Abstract
- Drug & regimen: 2 rounds for 2 consecutive years of dihydroartemisinin-piperaquine for 3 days, with the first dose administered directly house-to-house
- Concomitant interventions: IRS, LLINs, community engagement and the standard case management offered by the MoH
- Target size & population: The study population has 50,000 inhabitants
- Inclusion criteria: Older than 6 months of age or more than 5kg, women on the second or third trimester who are not on IPTp
- Exclusion criteria: Younger than 6 months of age or less than 5 kg, women in the first trimester of pregnancy, severely ill individuals and contraindications
- Outcome measures (primary and secondary) and tool used:
- Prevalence of malaria infection (by RDT and/or PCR) in a subgroup of the study population on month six
- Incidence of malaria as detected through passive case detection (weekly cases reported through a Rapid Reporting System)
- Identification of hotspots of maintained transmission in the study area
- Coverage achieved of MDA 1-4 rounds
- Time of follow-up: 12 months
- Clinicaltrials.gov ID: NCT02914145
Study Design
Type: Interventional
Allocation: Non-Randomized
Intervention model: Single group
Masking: None (open label)
Primary Purpose: Treatment
Thematic Categories
Date
Jan 2015 — Dec 2017
Funding Details
Project Site
Parent Project
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