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Last Updated: 18/06/2024

Mapping B-cell fate to improve humoral immunity to malaria

Objectives

To investigate the role of B-cell and T-cell to improve humoral immunity to malaria.

Principal Investigators / Focal Persons

Ashraful Haque

Rationale and Abstract

Malaria killed half a million people in 2019. While ~60 vaccines exist against viral or bacterial diseases, no effective vaccines exist against malaria-causing parasites. Immunity to malaria can be mediated by antibodies. This depends on immune cells called B- and T-cells, conducting a choreographed series of interactions in immune organs. This process appears defective in malaria for reasons unknown. This project will determine these reasons, and provide new ways for boosting immunity to malaria.

Thematic Categories

Vaccines (Immune Correlates)

Date

Nov 2021

Total Project Funding

$1.16M

Project Site

Australia

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