Last Updated: 05/04/2024
Managing insecticide resistance in Burkina Faso and Côte d’Ivoire (REACT): researches on new vector control strategies
Objectives
The objectives of this project are:
- To perform a Phase III randomized controlled trial of new vector control tools in combination with Long Lasting Insecticidal Nets (LLINs). The study will evaluate the benefit to use 1) insecticidal paints, 2) larvicides, 3) Ivermectin for both human and domestic animals and 4) a strengthened information, education and communication strategy to complement the universal coverage with LLINs through a cluster randomized trial.
- To assess the efficacy of each combination against malaria transmission, prevalence, and incidence.
- To assess the efficacy of each combination to manage insecticide resistance.
- To characterize the residual transmission and to assess its determinants.
- To study the behaviour of old, infectious and resistant Anopheles.
Principal Institution
Principal Investigators / Focal Persons
Study Design
Outcome measures:
- Primary outcome: malaria incidence (continuous monitoring during 2 years)
- Secondary outcomes: entomological inoculation rate and malaria prevalence
ClinicalTrials.gov Identifier: NCT03074435
| Study Type : | Interventional (Clinical Trial) |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Prevention |
Thematic Categories
Drug-based Strategies
Insecticide Resistance
Measurement of Transmission
Residual Transmission
Date
Jan 2016 — Dec 2018
Total Project Funding
$1.64M
Funding Details
Expertise France, France
EUR 1.5M
Project Site
