Last Updated: 18/09/2024

The malaria heart disease study

Objectives

The purpose of this study is to investigate the relationship between exposure to malaria and the risk of developing subclinical and manifest cardiovascular disease.

  • Aim 1: Determine whether prior exposure to malaria is associated with myocardial dysfunction.
  • Aim 2: Define the extent to which proinflammatory factors (such as Ang-2, CRP, VEGF) are associated with cardiac dysfunction in subjects with a history of malaria.
  • Aim 3: Determine if echocardiographic parameters of systolic and diastolic function and cardiac biomarkers are significantly elevated in patients with symptomatic malaria (N=200).
Principal Institution

Federal University of Acre, Brazil

Principal Investigators / Focal Persons

Philip Henrik Brainin Jensen

Rationale and Abstract

The Malaria Heart Disease Study is a prospective longitudinal cohort study of a random sample of approximately 1200 individuals from the state of Acre in Brazil. The overall hypothesis is that patients who have (i) previously suffered from a malaria infection or (ii) patients with ongoing symptomatic malaria will benefit from having an echocardiogram and blood tests performed as a screening tool to diagnose early cardiac impairment and prevent future cardiovascular disease.

Study Design
  • Clinical Trial registration: NCT04445103
  • Study type: Observational
  • Enrollment: 597
Thematic Categories

Basic Science

Date

Feb 2020 — Jan 2021

Total Project Funding

$216,740

Project Site

Brazil

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