Last Updated: 18/09/2024
The malaria heart disease study
Objectives
The purpose of this study is to investigate the relationship between exposure to malaria and the risk of developing subclinical and manifest cardiovascular disease.
- Aim 1: Determine whether prior exposure to malaria is associated with myocardial dysfunction.
- Aim 2: Define the extent to which proinflammatory factors (such as Ang-2, CRP, VEGF) are associated with cardiac dysfunction in subjects with a history of malaria.
- Aim 3: Determine if echocardiographic parameters of systolic and diastolic function and cardiac biomarkers are significantly elevated in patients with symptomatic malaria (N=200).
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
The Malaria Heart Disease Study is a prospective longitudinal cohort study of a random sample of approximately 1200 individuals from the state of Acre in Brazil. The overall hypothesis is that patients who have (i) previously suffered from a malaria infection or (ii) patients with ongoing symptomatic malaria will benefit from having an echocardiogram and blood tests performed as a screening tool to diagnose early cardiac impairment and prevent future cardiovascular disease.
Study Design
- Clinical Trial registration: NCT04445103
- Study type: Observational
- Enrollment: 597
External reference
Thematic Categories
Date
Feb 2020 — Jan 2021
Total Project Funding
$216,740
Project Site
Related Resources
