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Last Updated: 13/03/2023

Malaria, diabetes and metabolic syndrome: investigating the double burden of disease

Objectives

To investigate whether diabetes and obesity affects the risk of severe malaria, and whether these underlying conditions impact on the susceptibility to chronic asymptomatic parasitemia and antibody mediated immunity to malaria in adults.

Principal Institution

Karolinska Institute (KI), Sweden

Principal Investigators / Focal Persons

Simeon Pierre Choukem
Katja Wyss

Rationale and Abstract

Many sub-Saharan African countries are facing an increase in non-communicable diseases (NCDs), such as diabetes, obesity and metabolic syndrome due to lifestyle changes. At the same time infectious disease such as malaria remain highly endemic in these same areas. A recent study in Sweden detected a markedly increased risk of severe malaria in travellers with diabetes and obesity. Whether this is also found in endemic areas is yet to be confirmed. The purpose of this project is to establish a collaboration between institutions in Cameroon and Sweden; and to develop research projects to address the interplay between NCDs and malaria. We will perform a hospital-based study to assess disease severity and comorbidities. In addition, we will set up a cohort study to assess malaria parasite prevalence and immunity, as well as progress of diabetes. The proposed collaboration builds on highly complementary expertise that will enable generation of novel interdisciplinary findings of high public health importance. The collaboration includes workshops, seminars, research visits and planned PhD, and will be mutually beneficial for the research and development of both partners.

Thematic Categories

Combination of Interventions

Date

Dec 2020

Total Project Funding

$89,056

Funding Details
Swedish Research Council (SRC), Sweden

Grant number: 2020-05494_VR
SEK 800,000
Project Site

Cameroon
Sweden

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