Last Updated: 31/01/2025
Investigating the host-pathogen genetic interactions of Plasmodium falciparum, the causative agent of human malaria
Objectives
This project aims to use a combination of human and malaria genome sequencing to dissect host-parasite genetic interactions and expand existing datasets by sequencing ancient parasite DNA samples and to use the modern technique of single cell sequencing to enable in depth, highly powered analysis of malaria parasite genome evolution and function.
Malaria is a substantial public health problem responsible for approximately 409,000 deaths every year according to the World Health Organisation. Despite decades of research and significant financial investment an effective malaria vaccine is yet to be developed. Malaria parasites continually evolve to counteract human resistance traits and understanding how malaria parasites are changing could lead to the development of more effective vaccines and antimalarial drugs.
Oct 2021 — Oct 2024
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