Last Updated: 18/06/2024
Integrated research that contributes to the development of vaccines and drugs against protozoans and parasites that are problematic in Japan
Objectives
With regards to malaria this project will elucidate the molecular mechanism of artemisinin resistance in Plasmodium falciparum. In addition, the study will search for a constant region into which no P. falciparum mutation is introduced. In the development of a malaria vaccine, this project will elucidate the dormancy regulation mechanism by histone-modifying enzymes that control the dormancy and proliferation of malaria intrahepatic parasites.
This research focuses on the five diseases designated by the Infectious Diseases Law [Category 4: Malaria, Echinococcosis; Category 5: Entamoebiasis, Giardiasis, and Cryptosporidiosis], which are of concern in Japan. Aiming to develop new vaccines and drugs against protozoan and parasitic diseases, the project will develop research and development that contributes to these creations originating in Japan. In this joint research, for Entamoeba histolytica drug discovery, compounds with protozoan-killing effects were searched for from the compound library of the University of Tokyo drug discovery mechanism, excluded those with human cytotoxicity, and selected compounds with selective toxicity of 10 or more. With regard to Giardia, Trichomonas, and Acanthamoeba, the purpose is to search for substances that have a particularly killing effect on Acanthamoeba from actinomycete and fungal culture extract libraries. The project will develop new vaccines and drug research and development for seven protozoan and parasitic diseases that are problematic in Japan. The purpose of Entamoeba histolytica drug discovery is to search for compounds with protozoan-killing effects from the compound library of the University of Tokyo drug discovery mechanism, exclude those with human cytotoxicity, and select compounds with selective toxicity of 10 or more. do. With regard to Giardia, Trichomonas, and Acanthamoeba, the purpose is to search for substances that have a particularly killing effect on Acanthamoeba from actinomycete and fungal culture extract libraries. As for Giardia, Trichomonas and Acanthamoeba, the project will search for those with bactericidal activity from the library of actinomycetes and fungal culture extracts (4,000 types). In Echinococcus and Cryptosporidium drug discovery, we will search for enzyme activity inhibitory compounds from DDI (approximately 10,000) and the Kitasato University Natural Products Library (500).
Apr 2020 — Mar 2023
$230,704
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