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Last Updated: 09/06/2024
Impact of Seasonal Malaria Chemoprevention on the buildup of protective immunity and the protection against clinical malaria in Burkina Faso (ISCHEMIC)
Objectives
This project intends to establish the key elements for understanding the potential role of SMC in the buildup of immunity against clinical malaria in Burkina Faso. We propose to build upon collaborations between existing partners to address key knowledge gaps in our understanding on how SMC against Plasmodium falciparum infections affect during low and high transmission the following: i) parasite presence, ii) parasite density, iii) parasite diversity or clones and iv) host antibodies responses. We will establish the relationship between asexual parasite densities, multiclonal infections of Plasmodium falciparum, and immune responses before and after of SMC.
Seasonal Malaria Chemoprevention (SMC) is a new strategy to reduce the malaria burden in young children in Sahelian countries. SMC consists of the administration of full treatment courses at regular intervals during the malaria high transmission season. However, it is not clear if there is a cumulative effect of SMC overtime on the acquisition of antibodies to malaria antigens.
The researchers will conduct a prospective cohort study following the national health policy of SMC in Burkina Faso.
Feb 2020 — Jan 2023
$164,785
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