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Last Updated: 19/06/2024
Impact of elminths on immunogenicity of the RTS,S malaria vaccine in children
Objectives
To characterize children’s immune responses to the new malaria vaccine to determine the impact of any accompanying infections.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
The WHO recently approved a new malaria vaccine that will mainly be deployed in sub-Saharan Africa. During its development, HIV-infected children were found to mount weaker immune responses. Helminth infections, which are prevalent in sub-Saharan Africa, are also suspected to negatively impact vaccine efficacy. To test this, they will use an antibody-dynamics platform to assess the impact of helminths and other current or prior parasitic, bacterial, and viral infections on humoral and cellular immune responses following the 4th dose of the new malaria vaccine in two- to three-year-old children at six hospitals in western Kenya. This will help design more effective deployment strategies such as deworming before vaccination.
External reference
Thematic Categories
Date
Nov 2023 — Jun 2024
Total Project Funding
$249,947
Funding Details
Bill and Melinda Gates Foundation (BMGF), United States
Grand Challenges. Supporting Researchers Through the Technologies of the Global Health Discovery Collaboratory Platforms
Grant ID: inv-060681
Project Site
Related Resources
