Last Updated: 18/06/2024
Impact of metabolic resistance to pyrethroids on the vectorial competence of the major African malaria vector Anopheles funestus
Objectives
This project aims at establishing the impact of metabolic resistance on malaria transmission in Africa, to improve resistance management.
Specific objectives:
- Investigate the influence of metabolic resistance on the development of P. falciparum in An. funestus using GST and P450 markers.
- Characterize the transcriptomic changes accompanying P. falciparum infection in metabolic insecticide resistant An. funestus using RNAseq.
- Investigate interactions between metabolic resistance and Plasmodium immune response genes in An. funestus using functional genomics (RNAi).
Insecticide resistance is threatening effectiveness of insecticide-based interventions to control malaria across Africa. However, the impact of this resistance on malaria transmission remains a matter of debate. It is not yet well established whether insecticide resistance, particularly metabolic resistance, in addition to allow survival to insecticide exposure, positively or negatively affect capacity of vectors to develop and transmit malaria parasites. Taking advantage of the recent designs of the first simple DNA-based assays allowing to track cytochrome P450- and glutathione-S-transferase mediated metabolic resistance in the major malaria vector Anopheles funestus. This project will benefit from the expertise gained during the Wellcome Trust Training Fellowship including the successful rearing and establishment of experimental infections of field An. funestus using natural P. falciparum isolates.
Dec 2020 — Nov 2025
$929,564
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