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Last Updated: 12/07/2023
Immune and metabolic determinants of sexual conversion in host Plasmodium parasites (IMMETASEX).
Objectives
*Original title in Dutch: Immuun en metabole determinanten voor seksuele conversie in Plasmodium parasieten in de gastheer (IMMETASEX)
To develop a new tool that based on expression analysis of sexual stage biomarkers will estimate sexual conversion rates in natural infections to identify immune factors and metabolites that induce sexual conversion using in-house developed sexual conversion assays, and experimental mosquito infections.
Understanding the sexual conversion of the malaria parasite is essential to interrupt malaria transmission. At each replicating cycle within erythrocytes, a proportion of asexual parasites converts into non-replicative sexual stages, which are the only forms able to infect mosquitos. The rate at which sexual stages are produced, is known as basal sexual conversion rate. Changes in the host immune and metabolic environment associated with the development of malaria disease, such as depletion of lysophosphatidylcholine in plasma, have been associated with increased sexual conversion rates in vitro. The hypothesis is that immune and metabolite factors that are altered during malaria infection induce sexual conversion in Plasmodium falciparum parasites. The project we will also explore transcriptional mechanisms driving parasite sexual conversion in the host environment during disease using single cell RNA-sequencing approaches. This research will provide essential knowledge on the factors that affect sexual conversion in the host and potentially inform novel strategies to interrupt transmission.
Jan 2023 — Dec 2026
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