Last Updated: 01/10/2025
Identification of the inhibitory effect of D-allose on Plasmodium parasites in the midgut of Anopheles mosquitoes
Objectives
This study aims to identify factors in the midgut tissue that are important for the inhibitory mechanism in order to clarify the mechanism by which D-allose inhibits malaria parasite development. Specifically, the study will evaluate the effects of controlling each target gene by the RNAi method on the development and tissue invasion of malaria parasites.
Anopheles mosquitoes are vectors that transmit malaria parasites to humans. Malaria parasites develop in the midgut of Anopheles mosquitoes and invade the midgut tissue. However, it is unclear how this is determined. D-allose has an inhibitory effect on the development of malaria parasites in the midgut. The results of this study are expected to identify factors that determine the success or failure of malaria parasite infection and to provide a basis for the development of new vector control methods using sugars.
Apr 2024 — Mar 2027
$30,900
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