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Last Updated: 11/07/2024
Identification of Compounds Targeting Specifically Plasmodium malariae Malaria for its Elimination Along with Plasmodium falciparum
Objectives
To identify approved anti-malarial drugs that are effective also against the neglected malaria-causing pathogen Plasmodium malariae, which has become widespread in sub-Saharan Africa.
Principal Institution
University of Sciences Techniques and Technologies of Bamako (USTTB), Mali
Principal Investigators / Focal Persons
Partner Institutions
Partner Investigators
Rationale and Abstract
To eliminate malaria, treatments should be effective for all circulating malaria pathogens. However, current artemisinin-based combination therapies (ACTs) are largely designed to target the historically more prevalent P. falciparum species. They will recruit around 400 patients with uncomplicated malaria in Faladje to determine the P. malariae malaria burden. They will also evaluate the ability of a panel of anti-malarial compounds to destroy cultured P. malariae together with P. falciparum to help guide treatment strategies.
External reference
Thematic Categories
Date
Jul 2021 — May 2023
Total Project Funding
$100,000
Funding Details
Bill and Melinda Gates Foundation (BMGF), United States
Grand Challenges Africa. Grand Challenges Africa: Drug Discovery
Project Site
Related Resources
