Last Updated: 21/08/2024
Identification of a novel Plasmodium placental ligand involved in the onset of pregnancy malaria
Objectives
*Original title and text were machine translated from Japanese.
This study will comprehensively identify all of the malaria parasite proteins used for adhesion from the malaria parasites that attach to the placenta, across the genome of the parasite.
Red blood cells infected with Plasmodium falciparum attach to the surface of the placenta, causing a condition known as “gestational malaria,” which can be fatal to the mother and fetus. However, the mechanism is known only to involve one type of protozoan ligand protein in adhesion to the placenta, and the overall picture is largely unknown. This research will accelerate malaria countermeasures for pregnant women and fetuses, which are currently lagging behind the rest of the world.
Sep 2023 — Mar 2026
$157,135
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