Last Updated: 07/06/2023
Host and parasite factors influencing P. vivax RBC invasion and asexual development
Objectives
To rigorously assess the importance of red blood cell polymorphisms, host immunity and parasite factors in modulating the efficacy of red blood cell invasion and P. vivax intraerythrocytic development.
Plasmodium vivax threatens half of the world’s population and is surprisingly resilient to on-going malaria elimination efforts, partially due to its unique characteristics and our poor understanding of its biology. Here, the proposal is to conduct state-of-the-art transcriptomic analyses using materials derived directly from Cambodian patients to achieve the objective. The project will not only provide a better understanding of the fundamental molecular and cellular processes underlying blood stage P. vivax infections but will also provide a solid foundation to develop better malaria vaccines against this important but understudied human pathogen.
Jun 2022 — May 2027
$660,178
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