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Last Updated: 05/03/2018
Highly-sensitive RDT evaluation study in Myanmar
Objectives
The overall aim of this population cross-sectional survey is to identify foci that meet criteria for elimination interventions. qPCR and highly-sensitive RDTs will be compared to trigger focal MDA.
Primary objectives and outcomes at the individual levels:
- Evaluation of sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) for detection of Pf infection, as compared with qRT PCR.
- Define HRP2 concentration and its correlation to parasitemia
Primary objectives and outcomes at the population levels:
- Show that a low cost point of care tool such as the hsRDTs can be used as a surrogate for PCR to identify villages that meet criteria for elimination interventions.
Principal Investigators / Focal Persons
Rationale and Abstract
The population selected were residents of all ages in 39 villages, being 3668 individuals. 50 random individuals have been tested in each village by qPCR and exhaustive testing with RDT, hsRDTs and ELISA. Additionally, 36 villages and 1520 asymptomatic adults were included in the laboratory phase of the analysis.
Study Design
Population cross-sectional survey
Thematic Categories
Date
Mar 2016 — Jan 2018
Funding Details
Bill and Melinda Gates Foundation (BMGF), United States
Partly funded with the METF BMGF Grant OPP1177406
Project Site
Related Resources
