Highly-sensitive RDT evaluation study in Myanmar

Objectives

The overall aim of this population cross-sectional survey is to identify foci that meet criteria for elimination interventions. qPCR and highly-sensitive RDTs will be compared to trigger focal MDA.

Primary objectives and outcomes at the individual levels:

• Evaluation of sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) for detection of Pf infection, as compared with qRT PCR.
• Define HRP2 concentration and its correlation to parasitemia

Primary objectives and outcomes at the population levels:

• Show that a low cost point of care tool such as the hsRDTs can be used as a surrogate for PCR to identify villages that meet criteria for elimination interventions.