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Last Updated: 05/10/2023
Harnessing keratin from poultry feathers as potential cheap nano-formulation raw material for transdermal delivery of antimalarial combo-therapeutics: A proof-of-concept investigation
Objectives
The primary goal is to develop a transdermal nanocarrier encapsulating clotrimazole and miconazole nitrate each with artesunate to potentiate antimalarial activity and improve patient compliance in cerebral malaria (CM).
Principal Institution
Principal Investigators / Focal Persons
Partner Institutions
Rationale and Abstract
This research will design an innovative and versatile transdermal nanotool capable of overcoming non-compliance and enhancing treatment efficacy in cerebral malaria (CM), a key public health concern with an urgent need for more efficient and selective therapies, using keratin generated from chicken feather as a cheap readily-available bio- degradable pharmaceutical excipient. The nano-system is conceived to carry multiple drugs to optimize systemic pharmacological responses of artemisi- nin antimalarials. Results will expand the arsenal to fight malaria and provide a novel nanotool that can be extended to other applications where co-delivery of small-molecule drugs is needed.
External reference
Thematic Categories
Date
Jan 2021
Total Project Funding
$93,299
Funding Details
International Foundation For Science (IFS), Sweden
Grant ID: IFS-CAEA50E1
Project Site
