Last Updated: 05/10/2023
Harnessing keratin from poultry feathers as potential cheap nano-formulation raw material for transdermal delivery of antimalarial combo-therapeutics: A proof-of-concept investigation
Objectives
The primary goal is to develop a transdermal nanocarrier encapsulating clotrimazole and miconazole nitrate each with artesunate to potentiate antimalarial activity and improve patient compliance in cerebral malaria (CM).
This research will design an innovative and versatile transdermal nanotool capable of overcoming non-compliance and enhancing treatment efficacy in cerebral malaria (CM), a key public health concern with an urgent need for more efficient and selective therapies, using keratin generated from chicken feather as a cheap readily-available bio- degradable pharmaceutical excipient. The nano-system is conceived to carry multiple drugs to optimize systemic pharmacological responses of artemisi- nin antimalarials. Results will expand the arsenal to fight malaria and provide a novel nanotool that can be extended to other applications where co-delivery of small-molecule drugs is needed.
Jan 2021
$93,299
