Last Updated: 19/06/2024
Expression of malaria parasite mitochondrial protein in yeast and design of novel antimalarial compounds
Objectives
*Original title and abstract were machine translated from Japanese.
This study aims to express the function of Plasmodium malaria malic acid-quinone oxidoreductase (MQO) in yeast, which is easy to culture and carry out genetic recombination experiments, and understand its molecular properties.
Plasmodium mitochondrial malic acid-quinone oxidoreductase (MQO) is an important protein for energy metabolism in Plasmodium malaria and is expected to be a target molecule for selective antimalarial agents. Although ferulenol, a potent inhibitor of MQO, is a promising lead compound for selective antimalarial agents, the mode of binding of ferulenol required for drug design clues remains unclear. In addition the study further aims to create selective antimalarial agents by elucidating the binding mode of ferulenol by making full use of this yeast expression system and proceeding with analog synthesis based on the findings.
Apr 2022 — Mar 2025
$39,372
Related Resources
