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Last Updated: 12/07/2023
Evaluation of the paratransgenic potential of bacteria from the Serratia and Pantoea genera, symbionts of Anopheles darlingi, aiming at blocking the cycle of Plasmodium spp. in the mosquito vector
Objectives
*Original title in Portuguese: Avaliação do potencial paratransgênico de bactérias dos gêneros Serratia e Pantoea, simbiontes de Anopheles darlingi, visando o bloqueio do ciclo do Plasmodium spp. no mosquito vetor
The objective and abstract were machine translated to English.
To use genetically modified bacteria to generate a new and promising alternative, paratransgenesis, in the fight against malaria in northern Brazil.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Paratransgenesis involves the colonization of the gut of medically important insects with symbiotic bacteria, genetically modified to express antiparasitic effector molecules, which may inhibit the development of target parasites when they infect the insect vector. This technique is based on genetic engineering and has been gaining repercussions in the scientific community of several countries, especially for the control of malaria.
External reference
Thematic Categories
Date
Mar 2023
Funding Details
Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil
Grant number : 718796
Project Site
