Last Updated: 28/01/2025
Evaluation of the influence of polymorphisms in genes that encode cytokines and the production and levels of antibodies against Plasmodium falciparum proteins that are candidates for an antimalarial vaccine
Objectives
*Original title in Portuguese: Avaliação da influência de polimorfismos em genes que codificam citocinas e a produção e níveis de anticorpos contra proteínas de Plasmodium falciparum candidatas a vacina antimalárica
This project will evaluate the polymorphisms in the genes that encode the cytokines TNF-α, TGF-β, IL-10, IL-6, LTA and IFN-γ and to associate the presence of these polymorphisms with the production and levels of antibodies against Plasmodium falciparum protein candidates for antimalarial vaccine in populations naturally exposed to malaria in the Brazilian Amazon.
Malaria is a parasitic disease caused by protozoa of the genus Plasmodium. There are five species of Plasmodium that naturally parasitize humans, with P. falciparum being the species responsible for severe cases and mortality. A strategy of great impact would be the development of a vaccine capable of generating an effective immune response. However, evidence points to the influence of polymorphisms in cytokine-coding genes in the modulation of the specific immune response. The identification of genetic polymorphisms associated with the development of a specific immune response can help in the development of vaccine strategies. The study will be carried out in Mâncio Lima and Cruzeiro do Sul (AC) and Guajará (AM). Polymorphisms will be evaluated by PCR-sequencing and the humoral response will be evaluated by ELISA. The results will provide subsidies for the prevention and control of malaria. This project and its consent form were approved by the Research Ethics Committee of the Oswaldo Cruz Foundation (CEP-FIOCRUZ CAAE 46084015.1.0000.5248; 221/03).
May 2022
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