An evaluation of the cluster-randomised pilot implementation of RTS,S/AS01 through routine health systems in Ghana: A post-authorization observation study

On 1st May 2019, the Consortium to Evaluate Mosquirix in Ghana (CEM-GH) coordinated by Kintampo Health Research Centre of Research and Development Division of Ghana Health Service in collaboration with the Ministry of Health/Ghana Health Service and World Health Organization (WHO) started the pilot evaluation of the RTS,S Malaria Vaccine in Ghana including a series of 3 household surveys, and sentinel hospital and community mortality surveillance, building on routine systems. The 31st day of December 2022, marked forty-four (44) months of active evaluation activities in six regions of Ghana (Ahafo, Bono, Bono East, Central, Volta and Oti regions).

An observational evaluation of the pilot implementation of RTS,S/AS01 by the Ministry of Health/Ghana Health Service using a cluster-randomized design, with some areas (Districts) introducing RTS,S/AS01 malaria vaccine at the beginning of the programme (vaccinating areas) and other areas, initially without RTS,S/AS01, acting as comparison areas (non-vaccinating areas). Participants for study includes children living in the vaccinating and in non-vaccinating areas aged less than 5 years of age (Feasibility survey), who are hospitalized in 8 sentinel hospitals (sentinel hospital surveillance) and those whose deaths are reported in the vaccinating and in non-vaccinating areas (community mortality surveillance).

Surveillance
Vaccines (Immune Correlates)

Sep 2018 — Jun 2024

$5M

Ghana
Kenya
Malawi