Last Updated: 01/10/2025
Elucidation of the molecular mechanism by which a single nucleotide polymorphism in the mouse Apeh gene controls proliferation of the rodent malaria parasite
Objectives
This study aims to elucidate the molecular mechanism by which this single nucleotide polymorphism controls the proliferation of malaria parasites from two perspectives:
- the single nucleotide polymorphism in the Apeh gene changes the properties of red blood cells; and
- malaria parasites utilize APEH in red blood cells.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
The principal investigators found that a single nucleotide polymorphism in the acylpeptide hydrolase (APEH) gene strongly suppresses the proliferation of the rodent malaria parasite Plasmodium falciparum. However, the mechanism by which this single nucleotide polymorphism controls the proliferation of malaria parasites in red blood cells remains unknown.
External reference
Date
Apr 2024 — Mar 2027
Total Project Funding
$30,900
Funding Details
Project Site
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