Last Updated: 01/10/2025
Elucidation of the molecular cleavage mechanism of malaria parasite sporozoite tropism by Plasmepsin IX
Objectives
This study aims to clarify the processing mechanism of rhoptry proteins of sporozoites by plasmepsin IX, a protease localized in the rhoptry, as a stepping stone to clarify the mechanism of the highly efficient transmission of malaria parasites to mammals.
Rationale and Abstract
Malaria parasites develop in the mosquito body and become sporozoites, which are infectious to mammals. Sporozoites autonomously invade the mosquito’s salivary glands, are injected into the mammalian body when the mosquito bites blood, and reach the liver via the bloodstream, where they infect hepatocytes.
External reference
Themes
Date
Apr 2024 — Mar 2027
Total Project Funding
$30,900
Funding Details
Project Site
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