Last Updated: 06/10/2025
Elucidation of the mechanism of low-density malaria parasite infection based on field samples
Objectives
This study aims to test the hypothesis that exposure to mosquito vectors may play a role in connecting the external environment with the parasites in the human body, and that it may also change not only the parasite concentration but also the cell adhesion ability and population structure of the parasite, which contribute to pathogenicity by utilizing the samples from an intervention study in which infection rates were reduced by mosquito vector control measures.
Tropical falciparum malaria remains a major health issue for humankind. The background to sustained transmission is the presence of low-density malaria parasite infection. The applicants have demonstrated that such infections are frequently observed, particularly in areas where the population malaria infection rate has decreased, and contribute to sustained transmission. However, it is unclear how environmental changes such as decreased infection rates lead to decreased blood parasite concentrations.
Apr 2025 — Mar 2028
$30,892
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