Last Updated: 01/10/2025
Elucidation of the mechanism by which ferredoxin mutations in malaria parasites lead to drug resistance
Objectives
This study aims to clarify the mechanism of artemisinin resistance by closely examining the changes in protein function caused by this ferredoxin mutation and its impact on the metabolic network of malaria parasites.
In recent years, the emergence of strains resistant to artemisinin, a specific drug for malaria parasites, has become a major threat. It has been revealed that a mutation in the 97th amino acid (Asp to Tyr) of ferredoxin, an electron transfer protein possessed by malaria parasites, is strongly associated with this resistance. Elucidating the resistance mechanism will contribute to suppressing the emergence and spread of artemisinin-resistant parasites and advancing the eradication of malaria.
Apr 2024 — Mar 2027
$30,900
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