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Last Updated: 02/08/2024
Elucidation of the gene expression regulation mechanism in the red blood stage of malaria parasites
Objectives
*Original title and text were machine translated from Japanese.
This study aims to demonstrate that gene expression during the red endophase is controlled by a cascade of master transcription factors that comprehensively control each stage, that is, it can be understood as a chain of target genes (targetomes) of these transcription factors.
Principal Institution
Principal Investigators / Focal Persons
Partner Investigators
Rationale and Abstract
The red blood stage of malaria parasites is the most clinically important stage, but its transcriptional control mechanism is largely unknown. The red endophase consists of multiple stages, including merozoites (red blood cell invasion stage), trophozoites, and schizozoites. The belief is that elucidation of the transcriptional control mechanism on the genome scale will make it possible to understand this stage as a system, and will have a great impact on this research field.
External reference
Thematic Categories
Date
Apr 2023 — Mar 2026
Total Project Funding
$139,670
Funding Details
Project Site
Related Resources
