Last Updated: 02/10/2025
Elucidation of host tissue repair mechanisms in protozoan infections, particularly malaria
Objectives
The objectives of this project are to:
- elucidate the role of Plet-1 in protozoan infections using mice lacking the tissue repair-related molecule Placenta-expressed transcript 1 (Plet-1);
- clarify the molecular mechanism of tissue repair involving Plet-1 through proteomic and RNAseq analyses; and
- verify the effect of activating the tissue repair mechanism on alleviating symptoms of protozoan infections using mice with increased Plet-1 expression.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
This research not only demonstrates the importance of tissue repair mechanisms in protozoan infections, but also presents a new treatment strategy for protozoan infections that targets host factors, alleviating symptoms by activating the tissue repair mechanism.
External reference
Date
Apr 2024 — Mar 2027
Total Project Funding
$30,043
Funding Details
Project Site
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