Last Updated: 19/06/2024
Elucidation of lipid metabolism mechanism in mosquitoes and human hepatocytes of Plasmodium falciparum
Objectives
*Original title and abstract were machine translated from Japanese
This study clarifies the role of the stage-specific phospholipid biosynthesis system essential for the development of Plasmodium falciparum in the liver of mosquitoes and humans.
Plasmodium malaria requires large amounts of phospholipids because it proliferates rapidly in the liver and parts of the mosquito stage. In this study, a genetically modified P. falciparum was created that can knock out multiple molecules identified as phospholipid-metabolizing enzymes in a stage-specific manner in protozoa, and used these protozoa in the body of mosquitoes and in the primary human liver. To clarify the phospholipid biosynthetic molecules required for the development of protozoa in cells.
Apr 2022 — Mar 2025
$39,372
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